Which of the following cells are associated with myelofibrosis?

Teardrop cells are indeed associated with myelofibrosis, a type of bone marrow disorder in which the marrow is replaced by fibrous tissue. This condition leads to various hematological abnormalities, including ineffective hematopoiesis and the distortion of red blood cell (RBC) morphology.

In myelofibrosis, the presence of teardrop cells occurs due to the altered structure of the marrow environment as it becomes fibrotic. As the disrupted bone marrow creates difficulty for red blood cells to exit the marrow and enter circulation, the cells become misshapen, leading to the characteristic teardrop appearance. This morphological change reflects the pathology associated with the underlying disease process.

While normoblasts are immature red blood cells typically seen in normal erythropoiesis, lymphocytes are a type of white blood cell involved in the immune response, and blast cells are immature forms of hematopoietic cells found usually in higher quantities in acute leukemias. None of these cell types are specifically indicative of myelofibrosis in the same way that teardrop cells are. Thus, the association of teardrop cells with myelofibrosis is a recognized hallmark in the diagnostic identification of this disorder.