Which factors are associated with the intrinsic pathway of coagulation?

The intrinsic pathway of coagulation is primarily associated with factors that are activated when blood comes into contact with negatively charged surfaces or damaged endothelium. The factors specifically linked to this pathway include factor VIII, factor IX, factor XI, and factor XII, along with prekallikrein (PK) and high molecular weight kininogen (HMWK).

Factor VIII acts as a cofactor to factor IX, facilitating the conversion of factor X to Xa, while factor IX is activated by factor XI. Factor XI is, in turn, activated by factor XII, which initiates the intrinsic pathway when there is vascular damage. Prekallikrein and HMWK contribute to the stabilization of the intrinsic pathway by serving as cofactors in the activation of factor XII.

The other choices consist of factors from different pathways: for instance, factors I (fibrinogen), II (prothrombin), and V are part of the common pathway, while factors X and XIII also belong to the common and extrinsic pathways, respectively. However, they do not encompass the components specifically defining the intrinsic pathway. Therefore, the correct answer, which includes the key factors of the intrinsic pathway, accurately reflects the elements that are crucial for this specific coagulation