Which condition involves the presence of Dohle bodies?

Döhle bodies are cytoplasmic inclusions typically found in the neutrophils of individuals experiencing certain pathophysiological conditions, particularly infections and inflammatory responses. The presence of Döhle bodies is most commonly associated with sepsis, as they are indicative of the body's reaction to severe infections or systemic inflammation.

In septic processes, the bone marrow responds by producing an increased number of neutrophils, which may exhibit abnormal characteristics, including the formation of Döhle bodies. These structures are formed due to the retention of RNA during the maturation of the neutrophils and reflect a heightened state of activity within the immune system.

While other conditions may impact leukocyte morphology, the presence of Döhle bodies is most specifically linked with sepsis, highlighting the body's effort to combat the overwhelming infection. Therefore, understanding the role of Döhle bodies in sepsis is crucial for recognizing the implications of these cellular changes during diagnostic assessments and interpreting the laboratory findings associated with severe infections.