What is a characteristic finding in the alpha-2-globulin band during serum protein electrophoresis?

The characteristic finding in the alpha-2-globulin band during serum protein electrophoresis is haptoglobin. Haptoglobin plays a significant role in binding free hemoglobin that is released into the bloodstream during hemolysis. Its presence in the alpha-2-globulin band is indicative of various physiological conditions, including inflammatory responses and hemolytic anemia.

During electrophoresis, proteins are separated based on their size and charge, allowing for the identification of specific proteins within the serum. The alpha-2-globulin fraction is where haptoglobin is typically located, serving as a key marker in evaluating various clinical conditions and the overall health of the patient. When assessing serum protein levels, an increase in haptoglobin may suggest an acute-phase response or response to tissue damage.

Other choices represent proteins that do not typically migrate to the alpha-2-globulin band. Albumin is found in the albumin band and serves primarily as a carrier protein and stabilizer of oncotic pressure. Fibrinogen, a precursor to fibrin in blood clotting, is usually found in the gamma fraction. Beta-lipoprotein, associated with cholesterol transport, is part of the beta-globulin fraction. Thus, haptoglobin