How much whole blood protection does a full 300 ug dose of RhIg provide?

A full 300 µg dose of Rh immunoglobulin (RhIg) provides protection for approximately 30 ml of whole blood containing Rh-positive red blood cells. This dosage is essential for preventing Rh sensitization in Rh-negative individuals who may be exposed to Rh-positive blood, particularly during pregnancy or blood transfusions. The mechanism is based on the ability of RhIg to bind to and neutralize Rh-positive fetal blood cells, preventing the immune system of the Rh-negative individual from producing antibodies against Rh-positive antigens. This 30 ml of whole blood coverage is a critical measurement in transfusion medicine and helps ensure safe practice in maternal-fetal medicine and other clinical scenarios where Rh incompatibility is a concern.